ارتباط سطح ویسفاتین با متغیرهای آنتروپومتری و مقاومت به انسولین در زنان مبتلا به پره دیابت و دیابت نوع دو

Background: Visfatin is a protein secreted by visceral fat, which plays an important role in the pathogenesis of type 2 diabetes mellitus. Visfatin is also known as Pre-B Cell Colony Enhancing Factor or Nicotinamide Phosphoribosyl Transferase.  Visfatin is widely expressed in the visceral adipose tissue and has insulin-like metabolic functions. However, its pathophysiological role in human is still unknown. The aim of this study was to evaluate the relationship between plasma visfatin and obesity, and type 2 diabetes. Materials and Methods: This case-control study was conducted on 50 women with pre-diabetes and type 2 diabetes, and 50 healthy women. Visfatin and insulin levels were measured using a Mercodia ELISA kit (Mercodia Company, Sweden). The weight, height, waist circumference and FBS were determined using standard methods. Data was analyzed using SPSS software (Version 19). Results: According to the data, plasma visfatin levels increased in patients with prediabetes and type 2 diabetes compared to the control group (p<0/05). There was a meaningful correlation between visfatin and BMI, weight, waist circumference and HOMA-IR (p<0/05). No correlation was found between visfatin and FBS, and insulin in patients with prediabetes and type 2 diabetes. Conclusion: These results suggest that visfatin levels correlate with BMI, weight, and waist circumference, and can be used as a marker for the diagnosis and treatment of type 2 diabetes.